Sono Spine Laboratory | AI and Spine Surgery Research Laboratory

Research

研究テーマ

臨床現場の未解決課題を出発点として、画像AI、バイオメカニクス、分子生物学、再生医療を横断する研究を推進します。

🧠

AI-assisted Spinal Imaging

全脊椎X線・CT・MRI画像から解剖学的ランドマークを検出し、PI、PT、SS、LL、SVAなどの脊椎骨盤パラメータを自動化します。

Medical AI

📐

Spinal Alignment & Biomechanics

矢状面アライメント、LLIF/OLIFの矯正機序、ケージ圧、subsidenceリスクを定量化し、手術計画を高度化します。

Biomechanics

🧬

OPLL Molecular Biology

後縦靱帯骨化症・靱帯骨化の病態を、分子生物学、遺伝子発現、細胞機能解析から明らかにします。

OPLL

🦴

Intervertebral Disc Biology

椎間板変性の病態を、分子生物学、遺伝子発現、細胞機能解析から明らかにします。

Disc

🧫

Artificial Spinal Cord

慢性期脊髄損傷に対するscaffold-free人工脊髄の開発を通じて、再生医療の新たな治療選択肢を探ります。

Regeneration

🤝

Translational Spine Surgery

臨床研究、医工連携、多施設データ解析を組み合わせ、患者さんに還元可能なイノベーションを創出します。

Translation

Publications

論文一覧

主要論文・PubMed掲載論文。

Unilateral High-Riding Vertebral Artery Associates With the Progression of Atlantoaxial Joint Degeneration in Patients With Rheumatoid Arthritis.

Murata K, Fujii T, Otsuki B, Shimizu T, Sono T, Onishi A, Nakabo S, Murakami K, Tanaka M, Morinobu A, Matsuda S
International journal of rheumatic diseases (2026)
PMID: 42433164

Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

Shima K, Oishi N, Okada T, Duy Thuy DH, Fujibayashi S, Shimizu T, Murata K, Sono T, Otsuki B, Matsuda S, Isa T
Neurosurgery (2026)
PMID: 42377928

Comparative Study of Posterior Lumbar Interbody Fusion Using Expandable Cages versus Lateral Lumbar Interbody Fusion for Lumbar Canal Stenosis Associated with Osteoporotic Vertebral Fractures: A Multicenter Retrospective Cohort Study.

Tanaka A, Kimura H, Sono T, Shimizu Y, Kawaguchi S, Morizane K, Masuda S, Shimizu T, Odate S, Takemoto M, Otsuki B, Matsuda S
World neurosurgery (2026)
PMID: 42208934

Fibrin-Associated Large B-Cell Lymphoma Mimicking Pyogenic Spondylitis After Abdominal Aortic Graft Infection: A Case Report.

Fujita A, Sono T, Shimizu T, Murata K, Otsuki B, Haga H, Matsuda S
JBJS case connector (2026)
PMID: 41990144

Prevalence and progression of hip osteoarthritis in individuals with diffuse idiopathic skeletal hyperostosis.

Kubota M, Shimizu T, Sakamoto M, Yakami M, Sono T, Nakamoto R, Matsuda S, Otsuki B
Journal of bone and mineral metabolism (2026)
PMID: 41964711

Assessment of muscle quality and quantity in individuals with diffuse idiopathic skeletal hyperostosis.

Ono K, Shimizu T, Sakamoto M, Kubota M, Yakami M, Sono T, Nakamoto R, Murata K, Matsuda S, Otsuki B
Modern rheumatology (2026)
PMID: 41036673

Role of hip and lumbar flexion angles in stiffness-related disabilities with activities of daily living after lumbar spine surgery.

Sakamoto M, Otsuki B, Takemoto M, Kim Y, Tokuyasu H, Itaya T, Yamamoto Y, Murata K, Shimizu T, Sono T, Masuda S, Honda S, Shima K, Ikezaki T, Matsuda S
Journal of neurosurgery. Spine (2026)
PMID: 41650445

Anatomical Shifts of the Bowel During Positioning: Relevance to Prone Lateral Access Surgery.

Sono T, Iwata H, Onishi Y, Shimizu T, Murata K, Otsuki B, Matsuda S
Cureus (2026)
PMID: 41769443

Treatment trends and outcomes of pyogenic vertebral osteomyelitis in Japan, 2015-2023: A descriptive epidemiological study.

Yoshiyama T, Fukasawa T, Masuda S, Otsuki B, Murata K, Shimizu T, Sono T, Honda S, Shima K, Sakamoto M, Saito R, Matsuda S, Kawakami K
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (2026)
PMID: 40562610

Results of Spine Surgeries in Nonagenarians Compared with Octogenarians: A Propensity-Matched Analysis.

Sono T, Shimizu T, Murata K, Shima K, Sakamoto M, Saito R, Masuda S, Morizane K, Ono K, Shimizu Y, Yabe T, Tanaka A, Sakamoto Y, Kawaguchi S, Nakashima T, Tsubouchi N, Tomizawa T, Kanba Y, Kataoka T, Matsuda S, Otsuki B
World neurosurgery (2025)
PMID: 41022311

Correlation Between Quantitative Cage Pressure Measurements and Surgeons' Qualitative Tactile Assessments During Extraction in Lumbar Lateral Interbody Fusion: A Cadaveric Study.

Sono T, Shimizu T, Murata K, Yamamoto K, Matsuda S, Otsuki B
Spine (2025)
PMID: 39394653

Direct Repair of Bilateral Inferior Articular Process Fractures in a Young Athlete Using the Buck Method: A Case Report.

Saito R, Fujibayashi S, Sono T, Shimizu T, Murata K, Otsuki B, Matsuda S
JBJS case connector (2025)
PMID: 40705876

Comparison of Reoperation Incidence After Anterior Versus Posterior Decompression and Fusion for Cervical Ossification of the Posterior Longitudinal Ligament: Analysis of a Large Claims-based Database.

Masuda S, Fukasawa T, Otsuki B, Murata K, Shimizu T, Sono T, Honda S, Shima K, Sakamoto M, Matsuda S, Kawakami K
Clinical spine surgery (2025)
PMID: 40643125

Effect of Rheumatoid Arthritis on Postoperative Outcomes in Patients with Lumbar Spinal Disorders: A Systematic Review and Meta-Analysis.

Honda S, Murata K, Sakamoto M, Shiroshita A, Saka N, Otsuki B, Shimizu T, Sono T, Masuda S, Shima K, Matsuda S
Global spine journal (2025)
PMID: 39881528

Scoliosis progression after lung transplantation.

Shimizu T, Tanaka S, Otsuki B, Kawasaki K, Sono T, Murata K, Nakajima D, Matsuda S, Date H
The spine journal : official journal of the North American Spine Society (2025)
PMID: 39798609

Factors affecting indirect dural expansion in lateral interbody fusion for degenerative lumbar spondylolisthesis.

Shimizu T, Otsuki B, Masuda S, Sono T, Murata K, Matsuda S
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2025)
PMID: 39951147

Correspondence on 'Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration' by Fan et al.

Nishitani K, Kobori Y, Yoshitomi H, Murakami A, Murata K, Fujii T, Morita Y侑, Sono T, Matsuda S
Annals of the rheumatic diseases (2025)
PMID: 39915202

The Cross-Sectional Areas and Anterior-Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score-Matched Analysis.

Sono T, Ijiri K, Kakehi K, Masuda S, Shimizu T, Murata K, Matsuda S, Otsuki B
JOR spine (2025)
PMID: 39896130

Active Rheumatoid Arthritis and Scoliosis: A Mid-Term Cohort Study.

Honda S, Murata K, Otsuki B, Shimizu T, Sono T, Masuda S, Shima K, Sakamoto M, Fujii T, Onishi A, Murakami K, Onizawa H, Tanaka M, Morinobu A, Matsuda S
Spine (2025)
PMID: 38747218

Early prediction of functional impairment at hospital discharge in patients with osteoporotic vertebral fracture: a machine learning approach.

Masuda S, Fukasawa T, Inokuchi S, Otsuki B, Murata K, Shimizu T, Sono T, Honda S, Shima K, Sakamoto M, Matsuda S, Kawakami K
Scientific reports (2024)
PMID: 39732765

科学で脊椎外科を
再定義する。

研究テーマ

AI-assisted Spinal Imaging

Spinal Alignment & Biomechanics

OPLL Molecular Biology

Intervertebral Disc Biology

Artificial Spinal Cord

Translational Spine Surgery

最新情報

メンバー

論文一覧

共同研究・見学のご相談

科学で脊椎外科を再定義する。

研究テーマ

AI-assisted Spinal Imaging

Spinal Alignment & Biomechanics

OPLL Molecular Biology

Intervertebral Disc Biology

Artificial Spinal Cord

Translational Spine Surgery

最新情報

メンバー

論文一覧

共同研究・見学のご相談

科学で脊椎外科を
再定義する。